Debrisoquin is an isoquinoline-carboxamidine.
It was used to treat high blood pressure until it
was found to cause severe side effects in 5–10%
of the population. These persons have reduced
activity of a degrading enzyme, debrisoquin-4-
hydroxylase. A number of other medications,
including !-adrenergic blockers, antiarrhythmics,
and antidepressives, are also degraded by
this enzyme and may also cause untoward reactions
in persons with low activity. Individuals
with a slow rate of degradation show an increased
ratio of debrisoquin/4-hydrodebrisoquin
(1). The enzyme is coded for by the 450-
db1 gene, a member of the cytochrome P450-
IID family (CYP2D). Mutations may cause aberrant
splicing and produce a variant pre-mRNA
containing an additional intron
Subscribe to:
Post Comments (Atom)
No comments:
Post a Comment