Complex chemical substances, such as drugs or
plant toxins, are degraded by an oxidation system
(monooxygenases) in the endoplasmic reticulum
of liver cells. These enzymes (collectively
referred to as cytochrome P450) absorb
light maximally at 450 nm after binding to CO.
Cytochrome P450 is the last enzyme in the essential
electron-transporting chain in microsomes
of the liver and mitochondria of the
adrenal cortex. A large system of evolutionarily
related genes code for the different P450 proteins
in mammals.
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